The western portal of Central Kowloon Bypass (Yau Ma Tei Section) connects to the Yau Ma Tei Interchange and provides access to Western District, Kwai Chung, Lantau Island, Cheung Sha Wan, Yau Ma Tei and Tsim Sha Tsui via Hoi Po Road, West Kowloon Highway and Lin Cheung Road. The eastern portal connects to the Kai Tak Interchange and the Kowloon Bay road network, and motorists can travel via Shing Kai Road, Kai Cheung Road and Kai Fuk Road to and from Kai Tak Sports Park, Kowloon Bay, Kwun Tong and Kai Tak Cruise Terminal, etc.

The Central Kowloon Bypass (Yau Ma Tei Section) will also connect with the future Central Kowloon Bypass (Kowloon Bay Section) and the Tseung Kwan O-Lam Tin Tunnel, forming Route 6. This integration will further enhance connectivity within Hong Kong's road network and improve accessibility between districts.

The CKB will be a toll road, with tolls commencing when the entire CKB, including the Kowloon Bay Section, is fully commissioned in 2026.